Anne Clark
- Born: Abt 1744, Wilmington, New Hanover, NC
- Christened: 5 Feb 1743, Wilmington, New Hanover, NC
- Married: 16 Aug 1767, Boston, MA
- Died: 30 May 1795, New Hanover, NC
Anne married William Hooper Signer, son of William Hooper Rev and Mary Dennie, on 16 Aug 1767 in Boston, MA. (William Hooper Signer was born on 17 Jun 1742 in Boston, Suffolk, MA, died on 14 Oct 1790 in Hillsboro, Orange, NC and was buried in Hillsboro, NC, Old Town Cem.: Reburial Greencastle, NC.)
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